Sphingosine 1-phosphate receptor 2 is central to maintaining epidermal barrier homeostasis

We showed that S1P and its receptor S1PR2 are involved in maintaining the epidermal barrier homeostasis by controlling tight junction related proteins, corneodesmosin, and filaggrin2 expression.本研究揭示了S1P及其受体S1PR2在维持表皮屏障稳态中的作用，通过调控紧密连接相关蛋白、角化板蛋白和filaggrin2的表达来实现。