Erratum: Significant Associations between <i>CCL5 </i>Gene Polymorphisms and Post-Transplantational Diabetes Mellitus in Korean Renal Allograft Recipients

<i>Background:</i> Post-transplantational diabetes mellitus (PTDM) is a serious metabolic complication that may follow renal transplantation. The expression of chemokine (C-C motif) ligand 5 (CCL5) is inversely related to pancreatic β-cell function; thus, specific <i>CCL5</i> gene polymorphisms are considered to be risk factors for diabetes. In this study, we investigated the association between <i>CCL5</i> gene polymorphisms and the occurrence of PTDM in Korean patients who had undergone renal transplants. <i>Methods:</i> A total of 311 patients who had received kidney transplants without a prior history of diabetes were included. Three single nucleotide polymorphisms (SNPs) of the <i>CCL5 </i>gene were genotyped from genomic DNA with direct sequencing. <i>Results:</i> PTDM developed in 56 patients (18.0%). The results showed that the allele frequencies of <i>CCL5</i> gene polymorphisms, rs2107538*T, rs2280789*C and rs3817655*A were significantly higher in the patients with PTDM than in those without PTDM. In multiple logistic regression analysis, 3 SNPs (rs2107538, rs2280789 and rs3817655) of the <i>CCL5</i> gene were significantly associated with the development of PTDM in the codominant 2 and recessive models. Among haplotypes of the 3 polymorphisms, the frequency of the TCA haplotype was significantly higher in patients with PTDM than in those without PTDM. <i>Conclusions:</i> Our results indicated that genetic polymorphisms of the <i>CCL5</i> gene were associated with PTDM, suggesting that the <i>CCL5</i> gene might confer susceptibility to PTDM in patients who receive renal transplants.

<i>背景：</i> 移植后糖尿病（Post-transplantational diabetes mellitus, PTDM）是肾移植术后可能出现的严重代谢并发症。趋化因子C-C基序配体5（chemokine (C-C motif) ligand 5, CCL5）的表达水平与胰腺β细胞功能呈负相关，因此特定的<i>CCL5</i>基因多态性被视为糖尿病的危险因素。本研究针对韩国肾移植患者，探讨了<i>CCL5</i>基因多态性与PTDM发生之间的关联。<i>方法：</i> 本研究共纳入311例既往无糖尿病病史的肾移植受者。采用直接测序法对基因组DNA中的<i>CCL5</i>基因的3个单核苷酸多态性（single nucleotide polymorphisms, SNPs）进行基因分型。<i>结果：</i> 共有56例患者（18.0%）发生了PTDM。结果显示，PTDM患者的<i>CCL5</i>基因多态性rs2107538*T、rs2280789*C及rs3817655*A的等位基因频率显著高于未发生PTDM的患者。多因素logistic回归分析表明，<i>CCL5</i>基因的3个单核苷酸多态性位点rs2107538、rs2280789及rs3817655在共显性2模型和隐性模型中与PTDM的发生显著相关。在上述3个多态性位点构成的单倍型中，TCA单倍型在PTDM患者中的频率显著高于未发生PTDM的患者。<i>结论：</i> 本研究结果证实，<i>CCL5</i>基因的多态性与PTDM存在显著关联，提示<i>CCL5</i>基因可能会增加肾移植受者发生PTDM的易感性。

搜集汇总

背景与挑战

背景概述

该数据集关联一项关于CCL5基因多态性与韩国肾移植患者移植后糖尿病（PTDM）关联性的研究，包含311名无糖尿病史患者的基因分型数据，结果显示三个特定SNP（rs2107538、rs2280789、rs3817655）和TCA单倍型与PTDM风险显著相关。数据集提供原始研究数据，用于支持基因多态性在PTDM易感性中的分析，属于医学领域，遵循CC BY 4.0许可证。