Mechanistic basis and efficacy of targeting Beta Catenin-TCF7L2-JMJD6-MYC Axis to overcome resistance to BET inhibitors

NIAID Data Ecosystem2026-03-12 收录

BET抑制剂

β-catenin信号通路

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE145276 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2020-11-06

Beta-catenin in cholangiocytes regulates immune environment and wound healing after hepatobiliary injury. Beta-catenin in cholangiocytes regulates immune environment and wound healing after hepatobiliary injury

肝胆损伤修复

β-catenin信号通路

Identify differentially expressed genes in small mice cholangiocyte cell line (SMCC) when CTNNB1 is activated or silenced. Overall design: Totally 12 samples were included: 3 for CTNNB1 activation (SM

NIAID Data Ecosystem40

β-Catenin Signaling Biases Multipotent Lingual Epithelial Progenitors to Differentiate and Acquire Specific Taste Cell Fates

感觉细胞分化

β-catenin信号通路

Continuous taste bud cell renewal is essential to maintain taste function in adults; however, the molecular mechanisms that regulate taste cell turnover are unknown. Using inducible Cre-lox technology

NIAID Data Ecosystem20

Expression data from melanoma cancer cell line CHL-1 after Bromodomain and extra terminal domain inhibitor BAY 1238097 treatment

黑色素瘤转录组学

BET抑制剂

Bromodomain and extra terminal domain (BET) inhibtion reduces occupancy of BET-family at promoter and enhancer sites. This finally leads to genome wide changes in the transcription of specific genes.

NIAID Data Ecosystem10

DataSheet1_Irigenin inhibits glioblastoma progression through suppressing YAP/β-catenin signaling.zip

胶质母细胞瘤治疗

β-catenin信号通路

Glioblastoma (GBM) is the most malignant glioma in brain tumors with low survival and high recurrence rate. Irigenin, as an isoflavone compound extracted from Shegan, has shown many pharmacological fu

NIAID Data Ecosystem20

Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization

肿瘤转移机制

β-catenin信号通路

The tetraspanin CD63 is implicated in pro-metastatic signaling pathways, but so far, it is unclear how CD63 levels affect the tumor cell phenotype. Here, we investigated the effect of CD63 modulation

NIAID Data Ecosystem20

Mechanistic basis and efficacy of targeting Beta Catenin-TCF7L2-JMJD6-MYC Axis to overcome resistance to BET inhibitors

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