Table S2. Summary of potential off-target sites detected by GUIDE-seq analysis using the Bioconductor package GUIDE-seq. The table includes sites for both NmeCas9 (with N4GN3 PAM sequences) and SpyCas

Figshare2024-02-08 更新50

Genome-wide Profiling of off-targets from Prime editor in vitro and in vivo using PE-Tag

基因组编辑脱靶检测

Prime Editor基因编辑

Prime editors (PE) are robust genome-editing tools with a broad range of research and potential clinical applications. However, methods to delineate their genome-wide editing activities have relied on

NIAID Data Ecosystem40

Cytosine base editors induce prevalent unwanted out-of-protospacer editing and target-strand editing [Targeted amplicon sequencing]

基因组编辑脱靶检测

碱基编辑器安全性评估

The Detect-seq provides an unbiased method for genome-wide identification of CBE induced off-targets inside of cells. Purpose: Cytosine base editors (CBEs) have the potential to correct human path

NIAID Data Ecosystem50

Detect-seq on transfected HEK293T cells [Detect-seq data]. Detect-seq on transfected HEK293T cells [Detect-seq data]

基因组编辑脱靶检测

线粒体DNA编辑评估

We used a new technology, named Detect-seq, to perform genome sequencing on transfected HEK293T cells to see DdCBEs' off-target mutations. Besides, targeted-amplicon sequencing and ATAC-seq data were

NIAID Data Ecosystem50

Deep sequencing of CRISPR complex target sequences

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