Hepatocyte nuclear factor 1ß binding in E14.5 kidney

HNF-1ß mutations are one of the most common single-gene mutations that underlie kidney developmental disease. Hepatocyte nuclear factor 1ß (HNF-1ß) is essential for kidney development, but its functions in kidney development are incompletely understood. We identified 8284 HNF-1ß binding sites using ChIP-sequencing. The majority of these peaks map to promoter (26%), intron (34%) or distal intergenic regions (37.4%) of the mouse genome. 61% of peaks map to protein coding genes, 12% map to long-noncoding RNAs, and 2% map to miRNAs. Overall design: Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for HNF-1ß in embryonic day 14.5 mouse kidneys