Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p
The exon skipping mutations of the receptor tyrosine kinase MET (METex14), leading to oncogenic MET, are increasingly reported in cancers, including in 3-4% of non-small cell lung cancer (NSCLC). MET
Background Endoplasmic reticulum (ER) stress and its adaptive signaling through the unfolded protein response (UPR) are increasingly implicated in driving tumor progression and reshaping the tum
