Interleukin-4 receptor signaling modulates neuronal network activity

Neuroimmune interaction influences essential CNS processes. Hanuscheck et al. report expression of interleukin-4 receptor alpha at presynaptic terminals in mouse and human brain. Modulation of neuronal IL-R signaling alters the neuronal transcriptome, impacts synaptic transmission and causes anxiety-related behavior. Comparative gene expression profiling analysis of RNA-seq data for human iPSC derived neurons