Chiral N‑Phosphonyl Imines for an Aza-Morita–Baylis–Hillman Reaction via Group-Assisted Purification (GAP) Chemistry
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Seventeen examples of aza-Morita–Baylis–Hillman (aza-MBH) adducts have been synthesized by reacting chiral N-phosphonyl imines with acrylonitrile in good to excellent yields (up to 96%) and high diastereoselectivity (up to 99:1 dr). The synthesis of these adducts followed the method of group-assisted purification (GAP) chemistry, in which the pure aza-MBH products were readily obtained by washing the crude products with cosolvents of hexane and ethyl acetate.
创建时间：
2016-03-14
