Reprogramming to pluripotency through a somatic stem cell intermediate

ChEBI2014-03-28 更新2026-07-21 收录

干细胞重编程

细胞多能性诱导

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Reprogramming to pluripotency through a somatic stem cell intermediate

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2014-03-28

Effects of Reversine and RepSox on the Biological Characteristics of Sheep Fibroblasts by RNA sequencing analysis

干细胞重编程

小分子药物作用机制

RepSox could replace cMyc and Sox2 in the derivation of iPSCs. However, the molecular mechanisms of reversine and RepSox have not yet been clearly elucidated. Effects of Reversine on the biological ch

NIAID Data Ecosystem90

High-Efficiency Stem Cell Fusion-Mediated Assay Reveals Sall4 as an Enhancer of Reprogramming

干细胞重编程

细胞融合

Several methods allow reprogramming of differentiated somatic cells to embryonic stem cell-like cells. However, the process of reprogramming remains inefficient and the underlying molecular mechanisms

NIAID Data Ecosystem80

Establishment of Sheep Induced Pluripotent Stem Cells

干细胞重编程

畜牧生物技术

Inducing and establishinginduced pluripotent stem cells(iPSCs) can not only explain the mechanism of somatic reprogramming, but also lay a foundation for the establishment of sheep ESCs in vitro.In th

NIAID Data Ecosystem40

Excluding Oct4 from Yamanaka cocktail unleashes the developmental potential of iPSCs

干细胞重编程

表观遗传学

Oct4 is widely considered the most important among the four Yamanaka reprogramming factors. Here we show that the combination of Sox2, Klf4, and cMyc (SKM) suffices for reprogramming mouse somatic cel

NIAID Data Ecosystem80

OCT6 uniquely replaces OCT4 in inducing human pluripotency. Homo sapiens

干细胞重编程

多能性诱导机制

Somatic cells can be reprogrammed into pluripotent stem cells by the ectopic expression of OCT4, SOX2, KLF4, and c-MYC. Although SOX2, KLF4, and c-MYC (SKM) can be substituted by their respective fami

NIAID Data Ecosystem50

Reprogramming to pluripotency through a somatic stem cell intermediate

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