Multi-region Genomic for Esophageal Carcinoma

In this study, we performed whole-exome sequencing (WES) on 33 tissue samples from 6 esophageal cancer patients with lymph node metastasis, compared the differences of the genomic map and evolutionary map in different tissues, and then performed the pathway enrichment analysis on non-synonymous mutation genes. Finally, we sorted out the somatic mutation data of all patients to analyze the subclonality of each tumor.