alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+

Mitochondrial 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10; HADH2) catalyzes the reversible reaction of alpha-methyl-beta-hydroxybutyryl-CoA and NAD+ to form alpha-methylacetoacetyl-CoA and NADH + H+ (Ofman et al. 2003). Crystallographic data indicate that the enzyme is a homotetramer (Kissinger et al. 2004).线粒体3-羟基酰基辅酶A脱氢酶2型（HSD17B10；HADH2）催化α-甲基-β-羟基丁酰辅酶A与NAD+的可逆反应，生成α-甲基乙酰乙酸辅酶A及NADH + H+（Ofman等，2003年）。晶体学数据表明，该酶为同源四聚体（Kissinger等，2004年）。