Quality Assessment of Included Studies.

Jadad scale, points were determined as follows: I. generation of allocation sequence (computer-generated random numbers, 2 points; not described, 1 point; inappropriate method, 0 points); II. allocation concealment (central randomization, sealed envelopes or similar, 2 points; not described, 1 point; inappropriate or unused, 0 points); III. blindness (identical placebo tablets or similar, 2 points; inadequate or not described, 1 point; inappropriate or no double blinding, 0 points); IV. withdrawals and drop-outs (numbers and reasons are described, 1 point; not described, 0 points). The Jadad scale score ranges from 1 to 7; higher score indicates better RCT quality.Quality Assessment of Included Studies.