Alectinib Synthesis through Formal α‑Arylation of Enone
收藏NIAID Data Ecosystem2026-05-02 收录
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A new synthetic route for the synthesis of Alectinib, which is used as an adjuvant and first line of treatment in ALK-positive non-small cell lung cancer, is reported. The developed route starts from readily available starting materials (4-(4-methoxyphenyl)butyric acid or 2-ethyl anisole) and employs Suzuki–Miyaura cross-coupling and reductive cyclization as key steps. Good yield and no regioisomeric mixture formation are the key highlights of this route.
创建时间：
2025-08-24
