in order to study the changes of pulmonary immune microenvironment and various metabolic processes in Macaca leonina and Macaca mulatta after infected with SIV virus
The latent viral reservoir remains the major barrier to HIV cure, placing the burden of strict adherence to antiretroviral therapy (ART) on people living with HIV to prevent recrudescence of viremia.
The purpose of this experiment is to investigate the dynamic changes of circulating B cell subsets during the acute and chronic stages of SIV infection in rhesus macaques.