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资源简介：
mitochondrial DNA editing
应用场景：
创建时间：
2022-04-25
相关数据集
Homo sapiens Targeted Locus (Loci)
HDACi improve Cas9 and Cas9-mediated base editors
NIAID Data Ecosystem90
MitoKO: A library of base editors for precise ablation of all protein-coding genes in the mouse mitochondrial genome
We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous
NIAID Data Ecosystem70
C to G base editing in rice, tomato and poplar
C to G base editing in rice, tomato and poplar
NIAID Data Ecosystem50
De Novo Structural Mining and Engineering of New TadA Deaminases for Highly Efficient Adenine Base Editors
Protein function is primarily determined by tertiary structure, yet enzyme discovery has relied heavily on sequence homology. Here, we present a structure-guided mining framework integrating AlphaFold
NIAID Data Ecosystem70
Knockout of CMS-causative mitochondrial gene. Oryza sativa
To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN
NIAID Data Ecosystem60
