Robenidine, 1 (2,2′-bis[(4-chlorophenyl)methylene]carbonimidic dihydrazide), was active against MRSA and VRE with MIC’s of 8.1 and 4.7 μM, respectively. SAR revealed tolerance for 4-Cl isosteres wi

NIAID Data Ecosystem40

VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening

抗菌药物发现

抑制剂筛选

VIM-2-2, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening Descriptor: 2-(4-fluorophenyl)carbonylbenzoic acid, BETA-LACTAMASE, CHLORIDE I

Protein Data Bank Japan2024-01-10 更新20

Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation

结构导向药物设计

抗菌药物发现

Structure Guided Development of Novel Thymidine Mimetics targeting Pseudomonas aeruginosa Thymidylate Kinase: from Hit to Lead Generation Descriptor: 1-methyl-6-phenyl-1,3-dihydro-2H-imidazo[4,5-b]pyr

Protein Data Bank Japan2024-02-28 更新40

Table_2_Antibacterial Activity and Mechanism of Action of Aspidinol Against Multi-Drug-Resistant Methicillin-Resistant Staphylococcus aureus.DOCX

抗菌药物发现

MRSA耐药性

This study aimed at investigating the antibacterial activity of aspidinol, an extract from Dryopteris fragrans (L.) Schott, against methicillin-resistant Staphylococcus aureus (MRSA). MRSA isolates we

NIAID Data Ecosystem30

Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor

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