Development of a new model of Parkinson´s disease

To get insight the molecular mechanism underlying neuronal loss in Parkinson´s disease. We performed gene expression profiling analysis using data obtained from RNA-seq of midbrain of mice injected with an AAV control or an AAV expressing human tyrosinase that induces neuromelanin accumulation and subsequent neuronal loss. Comparative gene expression profiling analysis of RNA-seq data of midbrain of mice injected with an AAV control or an AAV expressing human tyrosinase.