HT-29 cells were treated with increasing concentrations of oxaliplatin (1–100 μM) in the presence or in the absence of PEA (10 μM). Incubation was allowed for 24h or 48h. Cell viability was measured b
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Highly fluorinated candidates containing anticancer pharmacophores like thiosemicarbazone (5a–e) and its cyclic analogues hydrazineylidenethiazolidine (6a–e), 2-aminothiadiazole (7a–e), and 2-hydrazin
BackgroundMetastasis is the major cause of cancer related death and targeting the process of metastasis has been proposed as a strategy to combat cancer. Therefore, to develop candidate drugs that tar
An Fe(II) complex with DPA-Bpy (DPA-Bpy = N,N-bis(2-pyridinylmethyl)-2,20-bipyridine-6 -methanamine) as the ligand was synthesized and characterized to mimic bleomycin. The binding constants (Kb) of t