Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719
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Cryo-EM structure of cancer-specific PI3Kalpha mutant E542K in complex with BYL-719 Descriptor: (2S)-N~1~-{4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl}pyrrolidine-1,2-dicarboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Authors: Liu, X, Zhou, Q, Hart, J.R, Xu, Y, Yang, S, Yang, D, Vogt, P.K, Wang, M.-W. Deposit date: 2022-09-11 Release date: 2022-12-07 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.77 Å) Cite: Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3K alpha. Proc.Natl.Acad.Sci.USA, 119, 2022
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2022-09-11
