Genome-wide association studies have identified statistically significant associations between genetic variants in or near the IKZF1 gene and several autoimmune disorders. IKZF1, encoding the transcri

NIAID Data Ecosystem30

Antitumor progenitor exhausted CD8 T cells are sustained with TCR engagement [WGBS]

肿瘤免疫学

T细胞表观遗传调控

Durability of an antitumor immune response is mediated in part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells, and in the absenc

NIAID Data Ecosystem10

Compendium of CD8+ T cell Data. Compendium of CD8+ T cell Data

T细胞表观遗传调控

感染免疫应答

Compendium of high-throughput sequencing datasets derived from murine CD8+ T cells responding to infection, profiled by RNA-seq, ChIP-seq, and ATAC-seq at Naïve, Effector, and Memory timepoints across

NIAID Data Ecosystem50

FoxP3 associates with enhancer-promoter loops to regulate Treg-specific gene expression [HiChIP]

T细胞表观遗传调控

染色质构象捕获

We applied proximity-ligation with chromatin immunoprecipitation (HiChIP) in Treg and closely related conventional CD4+ T cells (Tconv) to map the H3K27Ac, FoxP3 and Yy1 chromatin structures. Overall

NIAID Data Ecosystem30

Ikaros mediates gene silencing in T cells through Polycomb Repressive Complex 2

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