HEK293T MS - Representing dynamic biological networks with multi-scale probabilistic models
收藏NIAID Data Ecosystem2026-03-11 收录
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资源简介：
As an example of a comprehensive model of signal transduction, we provide a Wnt network that shows remarkable robustness under a range of phenotypical and pathological conditions. Its simulation allows the clarification of controversially discussed molecular mechanisms of Wnt signalling by predicting wet-lab measurements. A loss of Rac1 (Ras-related C3 botulinum toxin substrate 1) or JNK2 affected the TCF/LEF reporter whereas a loss of JNK1 had only mild effects, likely due to low abundance of JNK1.
创建时间：
2019-11-12
