Regulated endocleavage balances the degradation of nonsense-mediated decay substrates

ChEBI2017-06-01 更新2026-07-12 收录

无义介导mRNA降解

RNA代谢调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-3625 数据链接链接失效反馈

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Regulated endocleavage balances the degradation of nonsense-mediated decay substrates

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2017-06-01

Hyper-activation of nonsense-mediated mRNA decay in fragile X mental retardation syndrome. Homo sapiens

发育疾病分子机制

RNA代谢调控

"Fragile X mental retardation syndrome (FXS) is the most common single-gene cause of inherited intellectual disability, and it is highly associated with autism spectrum disorder. The disease is the re

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Small open reading frame-encoded protein production is modulated by nonsense-mediated decay in breast cancer. Small open reading frame-encoded protein production is modulated by nonsense-mediated decay in breast cancer

肿瘤新抗原

无义介导mRNA降解

Peptides from low abundance non-canonical proteins encoded by the human genome are presented by the major histocompatibility complex and serve as potential neoantigens or therapeutic targets. However,

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Oncogenic CDK13 Mutations Impede Nuclear RNA Surveillance [humanMut3primeseq]

RNA代谢调控

肿瘤机制研究

RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity. We find disrupted nuclear RNA surveillance is oncogenic. Cyclin Dependent Kinase 13 (CDK13) is mutated in mel

NIAID Data Ecosystem00

Nonsense-Mediated Decay restricts lncRNAs levels in yeast unless blocked by double-stranded RNA structure

无义介导mRNA降解

非编码RNA调控

Antisense long non-coding (aslnc)RNAs represent a substantial part of eukaryotic transcriptomes that are, in yeast, controlled by the Xrn1 exonuclease

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Small open reading frame-encoded protein production is modulated by nonsense-mediated decay in breast cancer - BT474

癌症新抗原

无义介导mRNA降解

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