<b>A cold stress-activated endocrine </b><b>sentinel</b><b> </b><b>chemical hormone</b><b> promotes</b><b> insect survival via mitochondrial adaptations</b><b> through the adipokinetic hormone receptor</b>

Here, we identify the endogenous ascaroside C9 (asc-C9) acts as a chemical signal that markedly improves survival following acute cold exposure by coupling lipolysis to mitochondrial adaptation.