The coactivator p300/CBP regulates genes by facilitating the assembly of transcriptional machinery and by acetylating histones and other factors. However, it remains mostly unclear how both functions

NIAID Data Ecosystem20

MOESM10 of Spermatid-specific linker histone HILS1 is a poor condenser of DNA and chromatin and preferentially associates with LINE-1 elements

精子染色质表观遗传学

转座子调控

Additional file 10: Table S7. LINE-1 subclass elements identification. Table represents the number of different types of subclasses of LINE-1 repeat elements associated with HILS1 and percentage of HI

Figshare2018-08-02 更新10

DNA virus infections shape transposable element activity in vitro and in vivo. DNA virus infections shape transposable element activity in vitro and in vivo

病毒-宿主基因组互作

转座子调控

DUX4 is known to be crucial for TEs induction during zygotic genome activation in early embryonic development. In adults, DUX4 is usually silenced and we previously showed that DUX4 expression is indu

NIAID Data Ecosystem30

MOV10 knockout and gene expression

转座子调控

转录组学分析

Transposable elements constitute nearly half of the mammalian genome and play important roles in genome evolution. While a multitude of both transcriptional and post-transcriptional mechanisms exist t

NIAID Data Ecosystem10

Interplay between Two Paralogous Human Silencing Hub (HuSH) Complexes in Regulating LINE-1 Element Silencing

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