Genomic control coefficient lambda λ_GC obtained for the different tests of association performed on the simulated scenario of stratification in regions R11 and R12.

aCochran-Mantel-Haenszel test accounting for the 2 different regions. bTest not corrected for population stratification. cTest corrected for population stratification using different number of PCs computed on different pruned MAF sets (i.e.; common.2 means that the PCs were computed on the common varint sets and 2 the test is adjusted on 2 such PCs). dTest performed using the mixed model implemented in EMMAX with the relatedness matrix computed either on the common, low frequency or rare variant sets.