Single-nucleus ATAC-seq profiling of the ventral spinal cord in an 11-month-old Cabin1 mutant mouse model of ALS

This project aims to elucidate the epigenetic mechanisms underlying Amyotrophic Lateral Sclerosis (ALS) pathogenesis associated with Cabin1 mutations. We performed single-nucleus ATAC-sequencing (snATAC-seq) on the ventral gray matter of the spinal cord from 11-month-old wild-type (WT) and heterozygous (Cabin1 HET) mice. The dataset consists of 3 samples (one WT and two HET). These data provide a high-resolution map of chromatin accessibility changes in the spinal cord during late-stage disease progression, facilitating the identification of regulatory elements and transcription factor networks disrupted by Cabin1 deficiency.