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Convergent Approach to (<i>E</i>)-Alkene and Cyclopropane Peptide Isosteres

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NIAID Data Ecosystem2026-03-06 收录
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Trisubstituted (E)-alkene isosteres (TEADIs) and novel cyclopropane amide bond isosteres (CPDIs) were synthesized by aldimine addition and three-component aldimine addition−cyclopropanation methodologies, respectively. These new peptide mimetics can serve as β-turn promoters.

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2016-05-06
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