Age and Gender Sub-group Analysis: Outcomes for each strategy evaluated based on specific age and gender sub-group analyses—including number needed to treat9^* and number needed to harm^# for each strategy as compared to status quo and ATP III (strategies listed in order of increasing effectiveness).

*The number needed to treat (NNT) is based on the number of people that need to be included in a given primary prevention strategy to prevent one CHD event as compared to either status quo or ATP III. #The number needed to harm (NNH) represents the number of people that would need to be included in a given primary prevention strategy in order for that strategy to lead to one more additional strategy-related adverse event (which include statin induced myopathy, rhabdomyolysis, hepatitis, liver failure, incident diabetes, and radiation associated malignancy from diagnostic cardiac imaging) as compared to either status quo or ATP III. ^Unable to calculate number needed to treat to allow this strategy to be more effective than ATP III, since ATP III led to fewer CHD events compared to the strategy being evaluated †Unable to calculate the number needed to harm to allow ATP III to be more effective than this strategy, since ATP III led to more medication related adverse events compared to the strategy being evaluated Age and Gender Sub-group Analysis: Outcomes for each strategy evaluated based on specific age and gender sub-group analyses—including number needed to treat9* and number needed to harm# for each strategy as compared to status quo and ATP III (strategies listed in order of increasing effectiveness).