Transcriptomic analysis of the effect of iron overload in human iPSC-CMs. Transcriptomic analysis of the effect of iron overload in human iPSC-CMs

We used human iPSC-CMs generated from healthy individuals and performed RNA-sequencing after 5 days of trastuzumab treatment to examine the mechanism associated with cardiac dysfunction in iPSC-CMs after iron treatment. Transcriptome analysis revealed broad changes in cardiovascular development and processes. Overall design: RNA profiling of 6 samples of trastuzumab- and no drug (control)-treated human iPSC-CMs