前额叶CRF神经元控制压力下的行为抉择数据集

个体面对压力会采取不同的行为应对方式。这种应对方式为生存所必需，也是对应激相关障碍的不同易感性的基础。促肾上腺皮质激素释放因子(CRF)和内侧前额叶在应激行为反应中的作用已被广泛研究，但内侧前额叶的CRF神经元的作用尚不清楚。本研究利用形态学、电生理学和钙成像方法发现，内侧前额叶的CRF神经元为一类GABA能抑制性神经元且直接参与悬尾应激反应。凋亡或化学遗传学抑制背内侧前额叶CRF神经元提高了悬尾和强迫游泳挑战下的不动时间，并诱导了社会回避行为，而CRF神经元的激活则具有相反的行为效果。此外，提高CRF神经元的活性促进了个体对重复社会失败应激的抵抗性。这些结果揭示了应激下内侧前额叶CRF神经元在双向控制行为选择中的关键作用。

Individuals adopt distinct behavioral coping strategies when exposed to stress. These coping strategies are essential for survival and underlie the differential susceptibility to stress-related disorders. The roles of corticotropin-releasing factor (CRF) and the medial prefrontal cortex (mPFC) in stress-related behavioral responses have been extensively studied, yet the function of CRF-expressing neurons in the medial prefrontal cortex remains unclear. This study employed morphological, electrophysiological, and calcium imaging approaches and found that CRF neurons in the medial prefrontal cortex are a subtype of GABAergic inhibitory neurons that directly participate in tail suspension stress responses. Apoptotic ablation or chemogenetic inhibition of CRF neurons in the dorsomedial prefrontal cortex increased immobility time during tail suspension and forced swim challenges, and induced social avoidance behaviors, whereas activation of these CRF neurons produced the opposite behavioral effects. Furthermore, enhancing the activity of CRF neurons promoted individual resilience to repeated social defeat stress. Collectively, these results reveal the critical role of medial prefrontal cortex CRF neurons in bidirectionally regulating behavioral selection under stressful conditions.

搜集汇总

背景与挑战

背景概述

该数据集聚焦于内侧前额叶皮层（mPFC）中促肾上腺皮质激素释放因子（CRF）神经元在压力下行为风格选择中的关键作用。通过形态学、电生理学和钙成像等方法，研究发现这些神经元是独特的GABA能抑制性中间神经元亚型，其活性双向调控压力下的行为反应，如消融或抑制会增加不动性和社交回避，而激活则增强韧性。数据集提供了相关的实验数据和图像，支持神经科学和精神病学领域的研究。