While oncogenes can potentially be inhibited with small molecules, the loss of tumor suppressors is more common and presents a conundrum for precision therapy because the proteins are no longer presen
BackgroundThe Drosophila melanogaster gene CG11501 is up regulated after a septic injury and was proposed to act as a negative regulator of the JAK/STAT signaling pathway. Diedel, the CG11501 gene pro
Triplet repeat siRNAs as found amplified in diseases such as Huntingtons disease can be used to kill cancer cells RNA isolated from HeyA8 cells 48 hrs after transfection with either a nontargeting siR
Transcriptional responses to external stimuli remain poorly understood. Using GRO-Seq and PRO-Seq, we show that CDK8 kinase activity promotes RNA polymerase II (RNAPII) pause release in response to IF
