Crohn's Disease WES meta results

Synopsis IBD exome-wide assocaition statistics from the meta-analysis of two callsets: Nextera and Twist. We used the fixed-effect meta-analysis in METAL. Column headers are self-explanatory. Allele2 is the tested/effect allele. Code availability Computer code used in this study: Hail (quality control, variants effect annotation; https://hail.is) SAIGE (variant-based and gene-based association test; https://github.com/weizhouUMICH/SAIGE) METAL (meta-analysis; https://genome.sph.umich.edu/wiki/METAL_Documentation) PLINK (ancestry assignment, IBD relatedness QC and sample heterozygosity QC; plink1.9, https://www.cog-genomics.org/plink/; sample level QC pipeline, https://github.com/Annefeng/PBK-QC-pipeline) Citation Sazonovs, Stevens, Venkataraman, Yuan et al., MedRxiv, 2021