Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma [ChIP-seq]
收藏NIAID Data Ecosystem2026-05-26 收录
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资源简介：
We used a CRISPR-based screening approach to identify functional vulnerabilities in pediatric sarcoma cell types, identifying BRD9 as an important dependency in synovial sarcoma cells. Overall design: ChIP-seq of BRD9, SS18-SSX1 in cells treated with BRD9 targeting degraders. ChIP-seq of steady state profiles of H3K27Ac and RNAPII. ChIP-seq of WT and mutant BRD9 proteins at steady state.
创建时间：
2019-02-23
