Supporting material for the submission to Endocrinology "Developmental Programming: Granulosa and Theca Cell-Specific Transcriptional Regulation by Prenatal Testosterone in Sheep"
Human primordial germ cells (hPGCs) are the embryonic precursors of sperm and eggs. While the exact temporal window of hPGC specification and the cellular identity of their precursors remains unclear,
Mitochondrial DNA (mtDNA) mutations cause inherited diseases and are implicated in the pathogenesis of common late-onset disorders, but it is not clear how they arise and propagate in the humans. Here
Small RNAs have critical roles for gene regulations and these abnormalities often lead to developmental arrest and/or diseases. Among small RNAs, we have focused on germ cell specific small RNA, named
