Proteins are intrinsically flexible macromolecules that undergo internal motions with time scales spanning femtoseconds to milliseconds. These fluctuations are implicated in the optimization of reacti
Nature has generated a wide variety of enzymes, all sharing the common objective of catalyzing specific reactions. Yet, enzymes have evolved and developed numerous strategies and structural features t
This study investigates the factors modulating the reactivity of 5'-deoxyadenosyl (5'dAdo•) radical, a potent hydrogen atom abstractor, present in the active sites of radical SAM enzymes, but otherwis