Dataset for Mathematical Model of in vitro Hepatocellular Cholesterol and Lipoprotein Metabolism, fig. 5
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A simulation showing the effect of statin therapy in the \textit{in vitro} experiment. Here a single dose of statin was applied at approximately $t =10$ h. The uptake of statin by the cells is followed by inhibition of cholesterol biosynthesis by HMGCR. This also leads to up-regulation of LDLR and PCSK9 mRNA transcription, which have a competing effect on LDL and VLDL levels. Yet, a reduction caused by the LDLR is more pronounced. The numerical results for an idealized statin that instantaneously halts transcription of HMGCR mRNA (11 doses) from are also presented [18].
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2022-01-28
