DHARANI Developing Human-Brain Atlas

We introduce DHARANI, the first online platform with three-dimensional (3D) histological reconstructions of the developing human brain from 14 to 24 gestational weeks (GW) across the five fetal brains. DHARANI features 5132 Nissl, hematoxylin and eosin stained, 20 µm coronal and sagittal sections, postmortem MRI, and a neuroanatomical atlas with 466 annotated sections covering ∼500 brain structures. It is accessible online at https://brainportal.humanbrain.in/publicview/index.html. The 3D reconstruction enables a volumetric view of the fetal brain, allowing visualization in all three planes ak...本研究介绍了DHARANI——全球首个可在线访问的平台，涵盖5例胎儿大脑在妊娠14至24孕周（gestational weeks，GW）阶段的发育中人脑三维（3D）组织学重建成果。DHARANI包含5132张经尼氏（Nissl）染色、苏木精-伊红（hematoxylin and eosin）染色的20μm冠状与矢状切面切片、死后磁共振成像（postmortem MRI）数据，以及覆盖约500个脑结构、包含466个标注切面的神经解剖图谱。该平台可通过以下网址在线访问：https://brainportal.humanbrain.in/publicview/index.html。此次三维重建可实现胎儿大脑的体可视化视图，支持在三个平面上进行可视化呈现……