One-Pot Asymmetric Synthesis of Substituted Piperidines by Exocyclic Chirality Induction
收藏NIAID Data Ecosystem2026-03-06 收录
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A highly efficient one-pot synthesis of substituted piperidines was developed through nitroalkene, amine, and enone condensation. The transformation was suitable for a large group of substrates, giving excellent yields and diastereoselectivity. Reactions using chiral amines revealed a chirality induction through the unusual exocyclic stereochemistry control, producing enantiomeric pure piperidines in simple steps.
创建时间：
2016-02-26
