RATIONALE: Drugs used in chemotherapy, such as liposome-encapsulated irinotecan hydrochloride PEP02, irinotecan hydrochloride, leucovorin calcium, and fluorouracil, work in different ways to stop the
(a) Competitive inhibition of LMDP in liposomes. The fluorescence peptide probe was incubated with Control-lipo (EPC/DOPE/CHEMS) or LMDP-lipo (EPC/DOPE/CHEMS/3 mol% LMDP) at the indicated LMDP concent
Supplementary Table 2. Quantification of peptide loading by mass loss, extraction or nitrogen analysis. Mean +/- SEM (n = 2). NA = quantification method not performed. Encapsulation efficiency (%) = p
Accumulation of intravenously injected cytotoxic liposomes in the skin induces serious toxicity. We used single time point and longitudinal intravital microscopy to understand skin accumulation dynami
