Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation

Transient state structure of CRISPR-Cpf1 (Cas12a) I5 conformation Descriptor: CRISPR-associated endonuclease Cas12a, DNA (5'-D(P*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*TP*AP*AP*CP*AP*AP*GP*CP*TP*CP*G)-3'), DNA (5'-D(P*CP*GP*AP*GP*CP*TP*CP*GP*TP*TP*AP*GP*AP*GP*AP*A)-3'), ... Authors: Montoya, G, Mesa, P, Stella, S. Deposit date: 2018-06-18 Release date: 2018-12-19 Last modified: 2024-05-15 Method: ELECTRON MICROSCOPY (3.63 Å) Cite: Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity. Cell, 175, 2018