Ratio of unphosphorylated TFV to phosphorylated TFV-DP by anatomic sampling sites.

Pairs are included if at least one value in the pair is above the limit of assay quantitation and the other is above the limit of assay detection. “N” is the number of pairs available meeting the inclusion criteria above. “Maximum N” is the number of possible pairs if all subjects at all visits provided a sample. Cmax only includes US participants where multiple serum samples were available; the pair is defined by serum Cmax matched with the corresponding PBMC TFV-DP concentration which is not necessarily peak TFV-DP after the same dose. Subscript “all” indicates that all PBMC-Serum pairs from each sample times are included, with participants contributing multiple pairs. All p<0.001 Wilcoxon signed rank test for TFV fmol/gm vs. TFV-DP fmol/gm. *Insufficient samples above the limit of assay quantitation and detection to estimate reliable medians given the inevaluable excluded pairs.