The Illumina Human Methylation EPIC array was used to assess methylation status at initial diagnosis in bone marrow or peripheral blood specimens from children with acute myeloid leukemia. Overall des
R2 values generated using linear modeling to compare average site-level methylation between plexing experiments. Average site-level methylation was calculated by averaging the percent methylation for
Methylation treated as a continuous outcome (M-values: PBC and COMBAT on chip) and menarcheal age category (>11 vs. ≤11 years) treated as a categorical exposure. Adjusting for age at blood collection,
