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Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.

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Kin = Unidirectional influx rate. Vi = Initial brain distribution volume. V0 = Vascular brain distribution volume, experimentally determined as the brain distribution volume of radioiodinated BSA. Vg = Tissue brain distribution volume. K1 = Unidirectional clearance or slope of the initial phase of the brain influx curve. K = Net clearance or slope of the plateau phase of the brain influx curve. Overview of the quantitative influx characteristics (± 65% confidence limits) of the five investigated CPPs based on linear and biphasic modeling of the multiple time regression analysis data.

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2015-10-14
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