Cleaned dataset for PubChem AID 1347036: qHTS assay of progesterone receptor (PR) agonists

This dataset is derived from PubChem BioAssay AID 1347036, titled "Progesterone receptor (PR) small molecule agonists, qHTS assay: Summary". The original assay is part of the Tox21 program and measures activation of progesterone receptor (PR) signaling using a beta-lactamase reporter assay in HEK293 cells engineered with a PR-responsive reporter system. Original dataset statistics: - Tested compounds: 7,671 - Active (agonists): 117 - Inactive: 7,408 Data preprocessing: - Removed duplicate entries based on compound identifiers. - Resolved conflicting labels by excluding compounds with inconsistent activity annotations. Final cleaned dataset: - Total compounds: 7,448 - Positive (agonists): 106 - Negative (inactive): 7,342