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Pd(0)-Catalyzed Decarboxylative Coupling and Tandem C–H Arylation/Decarboxylation for the Synthesis of Heteroaromatic Biaryls

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An effective Pd(0) carbene complex was successfully employed in the decarboxylative coupling of the heteroaromatic carboxylic acids (imidazo­[1,2-a]­pyridine and isoxazole) with aryl halides. For carboxyindoles, either decarboxylative coupling or tandem C–H arylation and decarboxylation occurred, leading to the formation of C2-monoarylated indoles.

创建时间:
2012-10-19
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