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Table S2 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation

NIAID Data Ecosystem2026-05-02 收录

数据链接：

https://figshare.com/articles/dataset/Table_S2_from_Synergistic_Effects_of_PARP_Inhibition_and_Cholesterol_Biosynthesis_Pathway_Modulation/28672615 数据链接链接失效反馈

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PARP1 PARP2 engagement (ITDR)

应用场景：

创建时间：

2024-09-16

PARP抑制剂研发

结构生物学

Human PARP1 (ARTD1) - Catalytic domain in complex with inhibitor ME0527 Descriptor: Poly [ADP-ribose] polymerase 1, SULFATE ION, ~{N}-[(1~{R})-1-(4-imidazol-1-ylphenyl)ethyl]-3-(4-oxidanylidene-1~{H}-

Protein Data Bank Japan2024-01-17 更新80

Senaparib: First Approval

PARP抑制剂研发

妇科肿瘤治疗

DeclarationsFunding The preparation of this review was not supported by any external funding.Authorship and Conflict of interest During the peer review process the manufacturer of the agent under revi

Figshare2025-07-30 更新80

PARP complexed with A906894

药物靶点结构解析

PARP抑制剂研发

PARP complexed with A906894 Descriptor: 3-oxo-2-piperidin-4-yl-2,3-dihydro-1H-isoindole-4-carboxamide, Poly [ADP-ribose] polymerase 1 Authors: Park, C.H. Deposit date: 2009-12-17 Release date: 2010-12

Protein Data Bank Japan2024-04-03 更新40

Tankyrase 1 with Phthalazinone 2

PARP抑制剂研发

蛋白质-药物复合物结构

Tankyrase 1 with Phthalazinone 2 Descriptor: (R,R)-2,3-BUTANEDIOL, 4-[bis(fluoranyl)-[3-[[(6~{S})-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5~{H}-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]carbonyl]phenyl]meth

Protein Data Bank Japan2024-03-06 更新80

Discovery of Quinazoline-2,4(1 H ,3 H )‑dione Derivatives Containing 3‑Substituted Piperizines as Potent PARP-1/2 InhibitorsDesign, Synthesis, In Vivo Antitumor Activity, and X‑ray Crystal Structure Analysis

PARP抑制剂研发

抗肿瘤药物临床前研究

Inhibiting PARP-1/2 offered an important arsenal for cancer treatments via interfering with DNA repair of cancer cells. Novel PARP-1/2 inhibitors were designed by capitalizing on methyl- or ethyl-subs

NIAID Data Ecosystem50

Table S2 from Synergistic Effects of PARP Inhibition and Cholesterol Biosynthesis Pathway Modulation

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