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资源简介：
RNA sequencing of Young and Old CD4 & CD8 T-cell subsets.
应用场景：
创建时间：
2021-06-03
相关数据集
Decreased production of IL-23, IL-12p70 and IL-12/23p40 in response to LPS+R848 stimulation in a subgroup of frail old individuals.
Whole blood cells from frail (n = 10) and non frail (n = 9) old individuals were stimulated with LPS+R848 during 24 h. IL-12/23p40, IL-12p70 and IL-23 were measured in cell-free supernatants by ELISA.
NIAID Data Ecosystem40
Data_Sheet_1_Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.PDF
In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic act
NIAID Data Ecosystem20
Expression data of young and aged mice derived CD8+ T cells stimulated in TCR or TRM condition for 3 days
Ageing can compromise antitumor immunity, but the underlying mechanism by which ageing causes CD8+ T cell dysfunction and thus limits their antitumor activity remains poorly understood. We found that
NIAID Data Ecosystem10
Age-related thymic involution modifies epithelial composition, function and T cell receptor repertoire
We aimed to investigate changes in T cell receptor (TCR) sequence repertoire over different ages in mouse thymocytes after negative selection. We used FACS to isolate M2 thymocytes from mice aged 1, 4
NIAID Data Ecosystem40
FcgRIIB+ and FcgRIIB- OT-I T cells d14 post OVA skin graft
Here, we sought to characterize the transcriptomes of FcγRIIB+ versus FcγRIIB- CD8+ T cells in a mouse model of transplant rejection to understand the function of FcγRIIB in programming CD8 T cells re
NIAID Data Ecosystem20
