Effect of naphthalene on gene expression of C57BL/6J mouse lung cells

Transcriptomic analysis on naphthalene exposed mouse lung cells was performed to discover molecular biomarkers for environmental toxin responses in respiratory orgnas. DEG analysis revelaed 293 genes with significant expression changes in naphthalene treated samples. GO enrichment analysis result showed GO terms related to cillum, axoneme and dynein complex were enriched in down-regulated genes and stress response terms in up-regulated genes. These results indicate when exposed to naphthalene, genes with increased expression levels are associated with chemical response and inflammation, while genes with decreased expression levels are associated with pseudostratified epithelical cells in respiratory organ. RNA-seq profiling of wildtype C57BL/6J male mouse lung cells after treated with naphthalene. 4 control samples and 4 naphthalene-treated samples was analyzed.