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Endothelial inhibition of the glycolytic activator PFKFB3 induces tumor vessel normalization, impairs metastasis and improves chemotherapy

ChEBI2016-11-17 更新2026-07-12 收录

血管正常化

癌症代谢治疗

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-4842 数据链接链接失效反馈

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Endothelial inhibition of the glycolytic activator PFKFB3 induces tumor vessel normalization, impairs metastasis and improves chemotherapy

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创建时间：

2016-11-17

癌症代谢治疗

转录调控机制

BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways and ATP levels sufficient to support translation. Crosstalk between th

NIAID Data Ecosystem50

BMP9 signaling promotes the normalization of tumor blood vessels

血管正常化

BMP信号通路

We sought to evaluate the effects of BMP9 on tumor vascular formation. We observed that BMP9 promotes vascular normalization with decreased permeability and increased perfusion and perivascular cell c

NIAID Data Ecosystem50

Nortriptyline-loaded liposomes promote radiotherapy efficacy by inducing tumor vascular normalization

血管正常化

药物递送系统

This is a low magnification scan image of a portion of the immunohistochemistry results from the window validation experiment. We believe they help can demonstrate that the size of the tumor did not e

NIAID Data Ecosystem00

Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma.. Beta-blockers disrupt mitochondrial bioenergetics and increase radiotherapy efficacy independently of beta-adrenergic receptors in medulloblastoma.

癌症代谢治疗

母细胞瘤药物机制

Our study showed that propranolol, carvedilol and nebivolol inhibited medulloblastoma cell proliferation and invasion by affecting energy metabolism pathways (OXPHOS and glycolysis) and by triggering

NIAID Data Ecosystem50

Genome scale metabolic models as tools for drug design and personalized medicine

药物靶点预测

癌症代谢治疗

In this work we aim to show how Genome Scale Metabolic Models (GSMMs) can be used as tools for drug design. By comparing the chemical structures of human metabolites (obtained using their KEGG indexes

Figshare2018-01-06 更新10

Endothelial inhibition of the glycolytic activator PFKFB3 induces tumor vessel normalization, impairs metastasis and improves chemotherapy

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