Diastereoselective Control of Intramolecular Aza-Michael Reactions Using Achiral Catalysts
收藏NIAID Data Ecosystem2026-03-07 收录
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资源简介：
An intramolecular aza-Michael reaction with a Cbz carbamate and an enone is reported to result in 3,5-disubstituted nitrogen-containing heterocycles. Either cis or trans isomers were obtained selectively using chiral substrates and an achiral Pd (II) complex or strong Brønsted acid catalysis. A range of substrates undergoes these selective transformations. Functionalization of the resulting products yielding bicyclic heterocycles is also demonstrated.
创建时间：
2016-02-22
